Hospitalisation and mortality risk of SARS-COV-2 variant omicron sub-lineage BA.2 compared to BA.1 in England.

The Omicron variant of SARS-CoV-2 became the globally dominant variant in early 2022. A sub-lineage of the Omicron variant (BA.2) was identified in England in January 2022. Here, we investigated hospitalisation and mortality risks of COVID-19 cases with the Omicron sub-lineage BA.2 (n = 258,875) compared to BA.1 (n = 984,337) in a large cohort study in England. We estimated the risk of hospital attendance, hospital admission or death using multivariable stratified proportional hazards regression models. After adjustment for confounders, BA.2 cases had lower or similar risks of death (HR = 0.80, 95% CI 0.71-0.90), hospital admission (HR = 0.88, 95% CI 0.83-0.94) and any hospital attendance (HR = 0.98, 95% CI 0.95-1.01). These findings that the risk of severe outcomes following infection with BA.2 SARS-CoV-2 was slightly lower or equivalent to the BA.1 sub-lineage can inform public health strategies in countries where BA.2 is spreading.

How has Covid-19 Affected Published Academic Research? A Content Analysis of Journal Articles Mentioning the Virus

Methods to tackle Covid-19 have been developed by a wave of biomedical research but the pandemic has also influenced many aspects of society, generating a need for research into its consequences, and potentially changing the way existing topics are investigated. This article investigates the nature of this influence on the wider academic research mission. This article reports an inductive content analysis of 500 randomly selected journal articles mentioning Covid-19, as recorded by the Dimensions scholarly database on 19 March 2021. Covid-19 mentions were coded for the influence of the disease on the research. Whilst two thirds of these articles were about biomedicine (e.g. treatments, vaccines, virology), or health services in response to Covid-19, others covered the pandemic economy, society, safety, or education. In addition, some articles were not about the pandemic but stated that Covid-19 had increased or decreased the value of the reported research or changed the context in which it was conducted. The findings relate only to Covid-19 influences declared in published journal articles. Research managers and funders should consider whether their current procedures are effective in supporting researchers to address the evolving demands of pandemic societies, particularly in terms of timeliness. The results show that although health research dominates the academic response to Covid-19, it is more widely disrupting academic research with new demands and challenges. © 2021 Sciendo. All rights reserved.

A thematic analysis of highly retweeted early COVID-19 tweets: consensus, information, dissent and lockdown life

Purpose: Public attitudes towards COVID-19 and social distancing are critical in reducing its spread. It is therefore important to understand public reactions and information dissemination in all major forms, including on social media. This article investigates important issues reflected on Twitter in the early stages of the public reaction to COVID-19. Design/methodology/approach: A thematic analysis of the most retweeted English-language tweets mentioning COVID-19 during March 10–29, 2020. Findings: The main themes identified for the 87 qualifying tweets accounting for 14 million retweets were: lockdown life;attitude towards social restrictions;politics;safety messages;people with COVID-19;support for key workers;work;and COVID-19 facts/news. Research limitations/implications: Twitter played many positive roles, mainly through unofficial tweets. Users shared social distancing information, helped build support for social distancing, criticised government responses, expressed support for key workers and helped each other cope with social isolation. A few popular tweets not supporting social distancing show that government messages sometimes failed. Practical implications: Public health campaigns in future may consider encouraging grass roots social web activity to support campaign goals. At a methodological level, analysing retweet counts emphasised politics and ignored practical implementation issues. Originality/value: This is the first qualitative analysis of general COVID-19-related retweeting. © 2020, Emerald Publishing Limited.